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It pays to do a little research before submitting an unsolicited manuscript to a publishing house. Some publishers don't accept such manuscripts, and submissions received are unceremoniously tossed into the trash. Check out the publishing house online - most will have a page that lists the requirements for submission.
If you hope to have the manuscript returned, include a self-addressed, stamped envelope which includes sufficient postage with your submissions. Be aware that publishers are under no obligation to return manuscripts. ALWAYS make sure you keep a copy of any manuscript sent out, and keep records as to where it has been submitted. Specify to the publisher if you are submitting to them alone, or to other publishers simultaneously.